长聘教轨副教授
基于CRISPR等的合成生物学工具深度开发，动态转录翻译调控平台的搭建等。
充分应用自主开发的使能工具结合计算生物学设计构建可与重要生物活性化合物绿色智能制造，重要环境污染物降解以及疾病治疗领域对接的微生物细胞工厂。
研究微生物个体在群体中的决策，社会性行为，以及潜在的在生物技术以及合成生物学中的应用价值。
Chia, N., Lee, S.Y.* Tong, Y.*, Optogenetic tools for microbial synthetic biology. Biotechnol. Adv. 59, 107953 (2022).
Tong, Y.*, Jørgensen, T.S., Whitford, C.M., Weber, T.*, Lee, S.Y.* A versatile genetic engineering toolkit for E. coli based on CRISPR-prime editing. Nature Communications. 12, 5206 (2021).
Tong, Y.*, #, Zhang, J.#, Wang, L., Wang, Q., Huang, H., Chen, X., Zhang, Q., Li, H., Sun, N., Liu, G., Zhang, B., Song, F., Alterovitz, G., Dai, H.*, Zhang, L.* Hyper-synergistic antifungal activity of rapamycin and peptide-like compounds against Candida albicans orthogonally via Tor1 kinase. ACS Infectious Diseases. 7, 2826-2835. (2021).
Tong, Y.*, #, Zhang, J.#, Sun, N. #, Wang, X. #, Wei, Q., Zhang, Y., Huang, R., Pu, Y., Dai, H., Ren, B., Pei, G., Song, F., Zhu, G., Wang, X., Xia, X., Chen, X., Jiang, L., Zhang, J., Ouyang, L., Zhang, B., Jiang, Y., Liu, X., Calderone, R., Bai, F.*, Zhang, L.*, Alterovitz, G. Berberine reverses multidrug resistance in Candida albicans by hijacking the drug efflux pump Mdr1p. Science Bulletin. 66, 1895-1905. (2021).
Tong, Y.*, #, Zhang, J.#, Sun, N. #, Wang, X. #, Wei, Q., Zhang, Y., Huang, R., Pu, Y., Dai, H., Ren, B., Pei, G., Song, F., Zhu, G., Wang, X., Xia, X., Chen, X., Jiang, L., Zhang, J., Ouyang, L., Zhang, B., Jiang, Y., Liu, X., Calderone, R., Bai, F.*, Zhang, L.*, Alterovitz, G. Berberine reverses multidrug resistance in Candida albicans by hijacking the drug efflux pump Mdr1p. Science Bulletin. 66, 1895-1905. (2021).
Tong, Y., Whitford, C. M., Blin, K., Jørgensen, T. S., Weber, T.*, Lee, S. Y.* CRISPR-Cas9-based, CRISPRi, and CRISPR-BEST-mediated genetic manipulation in streptomycetes. Nature Protocols. 15, 2470-2502. (2020).
Tong, Y.*, Deng, Z.*, An aurora of natural products-based drug discovery is coming. Synthetic and Systems Biotechnology. 5, 92-96 (2020).
Tong, Y., Whitford, C. M., Robertsen, H. L., Blin, K., Jørgensen, T. S., Klitgaard, A. K., Weber, T.*, Lee, S. Y.* Highly efficient DSB-free base editing for streptomycetes with CRISPR-BEST. Proc. Natl. Acad. Sci. U.S.A., 116, 20366-20375 (2019).
Tong, Y., Weber, T.*, Lee, S. Y.* CRISPR/Cas-based genome engineering in natural product discovery. Nat. Prod. Rep. 36, 1262-1280 (2019). Journal cover paper.
Tong, Y.*,#, Liu, M.#, Zhang, Y., Liu, X., Huang, R., Song, F., Dai, H., Ren, B., Sun, N., Pei, G., Bian, J., Jia, X-M., Huang, G., Zhou, X., Li, S., Zhang, B., Fukuda, T., Tomoda, H.,Ōmura, S., Cannon, R.D., Calderone, R., Zhang, L.* Beauvericin counteracted multi-drug resistant Candida albicans by blocking ABC transporters. Synthetic and Systems Biotechnology. 1, 158-168. (2016).
Best innovation award of Novo Nordisk Foundation Center for Biosustainability, 2015
浦江创新论坛-寻找青年的声音2021
现授“生命科学前沿：合成生物学”（研究生），春季学期-
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